Senter for psykofarmakologi

Publikasjoner

Det er betydelig forskningsaktivitet ved Senter for psykofarmakologi.

Under finner du alle artikler publisert de siste seks årene.

Publisert 07.03.2019 / Sist oppdatert 07.04.2021

2021

Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis. Milosavljevic F, Bukvic N, Pavlovic Z, Miljevic C, Pešic V, Molden E, Ingelman-Sundberg M, Leucht S, Jukic MM. JAMA Psychiatry. 2021 Mar 1;78(3):270-280.
Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders.
Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E. Schizophr Res. 2021 Feb;228:590-596.
Impact of age and CYP2D6 genotype on exposure of zuclopenthixol in patients using long-acting injectable versus oral formulation-an observational study including 2044 patients. Tveito M, Smith RL, Molden E, Høiseth G.
Eur J Clin Pharmacol. 2021 Feb;77(2):215-221.
Alcohol Consumption, HDL-Cholesterol and Incidence of Colon and Rectal Cancer: A Prospective Cohort Study Including 250,010 Participants. Tverdal A, Høiseth G, Magnus P, Næss Ø, Selmer R, Knudsen GP, Mørland J. Alcohol Alcohol. 2021 Feb 19:agab007. doi: 10.1093/alcalc/agab007. Online ahead of print. PMID: 33604595
Binge drinking and risk of ischemic heart disease and stroke: a study of pooled Norwegian health surveys. Degerud E, Høiseth G, Mørland J, Ariansen I, Graff-Iversen S, Ystrom E, Zuccolo L, Tell GS, Næss Ø. Am J Epidemiol. 2021 Mar 15:kwab063. doi: 10.1093/aje/kwab063. Online ahead of print. PMID: 33720294
Impact of age and gender on paliperidone exposure in patients after administration of long-acting injectable formulations-an observational study using blood samples from 1223 patients. Tveito M, Høiseth G, Haslemo T, Molden E, Smith RL. Eur J Clin Pharmacol. 2021 Feb 22. doi: 10.1007/s00228-021-03114-z. Online ahead of print. PMID: 33616704
Impairment of endoxifen formation in tamoxifen-treated premenopausal breast cancer patients carrying reduced-function CYP2D6 alleles.
Thorén L, Lindh JD, Ackehed G, Kringen MK, Hall P, Bergh J, Molden E, Margolin S, Eliasson E. Br J Clin Pharmacol. 2021 Mar;87(3):1243-1252.
Correlation of Body Weight and Composition With Hepatic Activities of Cytochrome P450 Enzymes. Krogstad V, Peric A, Robertsen I, Kringen MK, Vistnes M, Hjelmesæth J, Sandbu R, Johnson LK, Angeles PC, Jansson-Löfmark R, Karlsson C, Andersson S, Åsberg A, Andersson TB, Christensen H. J Pharm Sci. 2021 Jan;110(1):432-437.
A novel CYP2C-haplotype associated with ultrarapid metabolism of escitalopram.
Bråten LS, Haslemo T, Jukic MM, Ivanov M, Ingelman-Sundberg M, Molden E, Kringen MK. Clin Pharmacol Ther. 2021 Mar 24. doi: 10.1002/cpt.2233. Online ahead of print. PMID: 33759177
European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed. Schoretsanitis G, Smith RL, Molden E, Solismaa A, Seppälä N, Kopeček M, Švancer P, Olmos I, Vázquez M, Iglesias-Garcia C, Iglesias-Alonso A, Spina E, de Leon J. J Clin Psychopharmacol. 2021 Mar-Apr 01;41(2):140-147.
Evaluation of the CYP2D6 haplotype activity scores based on metabolic ratios of 4,700 patients treated with three different CYP2D6 substrates. Jukić MM, Smith RL, Molden E, Ingelman-Sundberg M.Clin Pharmacol Ther. 2021 Mar 31. doi: 10.1002/cpt.2246. Online ahead of print. PMID: 33792048

2020

Rates of complete nonadherence among atypical antipsychotic drugs: A study using blood samples from 13,217 outpatients with psychotic disorders.
Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E. Schizophr Res. 2020 Nov 18:S0920-9964(20)30565-X. doi: 10.1016/j.schres.2020.11.025
Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol. Waade RB, Solhaug V, Høiseth G.
Br J Clin Pharmacol. 2020 Oct 28. doi: 10.1111/bcp.14626
Bruk av farmakogenetiske tester i psykiatrien. Haslemo T, Solhaug V. NFT. 2020 des 14; 9: 38-41.
The Relationship Between Ingested Dose of Ethanol and Amount of Ethyl Glucuronide Formed in Blood. Fosen JT, Mørland J, Høiseth G.
J Anal Toxicol. 2020 Dec 12;44(8):861-863.

Use of Antidepressants in Older People during a 10-Year Period: An Observational Study on Prescribed Doses and Serum Levels.
Tveit K, Hermann M, Waade RB, Nilsen RM, Wallerstedt SM, Molden E.
Drugs Aging. 2020 Sep;37(9):691-701. doi: 10.1007/s40266-020-00784-9
Nøytropeni ved behandling med antipsykotika. Torp HA, Nystøy B. Tidsskr Nor Laegeforen. 2020 May 25;140(8).
Undetectable or subtherapeutic serum levels of antipsychotic drugs preceding switch to clozapine. Kyllesø L, Smith RL, Karlstad Ø, Andreassen OA, Molden E.
NPJ Schizophr. 2020 Jul 17;6(1):17.
Adverse effects information in clinical guidelines on pharmacological treatment of depression in children and adolescents: a systematic review. Westergren T, Narum S, Klemp M. BMJ Open. 2020 Jul 20;10(7):e036412. doi: 10.1136/bmjopen-2019-036412.
Identification of a novel polymorphism associated with reduced clozapine concentration in schizophrenia patients-a genome-wide association study adjusting for smoking habits.
Smith RL, O'Connell K, Athanasiu L, Djurovic S, Kringen MK, Andreassen OA, Molden E. Transl Psychiatry. 2020 Jun 19;10(1):198. doi: 10.1038/s41398-020-00888-1.

Impact of antipsychotic polypharmacy on nonadherence of oral antipsychotic drugs - A study based on blood sample analyses from 24,239 patients.
Smith RL, Tveito M, Kyllesø L, Jukic MM, Ingelman-Sundberg M, Andreassen OA, Molden E. Eur Neuropsychopharmacol. 2020 Aug;37:64-69. doi: 10.1016/j.euroneuro.2020.06.007.
Effect of Clinical Geriatric Assessments and Collaborative Medication Reviews by Geriatrician and Family Physician for Improving Health-Related Quality of Life in Home-Dwelling Older Patients Receiving Polypharmacy: A Cluster Randomized Clinical Trial. Romskaug R, Skovlund E, Straand J, Molden E, Kersten H, Pitkala KH, Lundqvist C, Wyller TB. JAMA Intern Med. 2020 Feb 1;180(2):181-189.
The Relation Between Ingested Dose of Ethanol and Amount of Ethyl Glucuronide Formed in Blood. Fosen JT, Mørland J, Høiseth G.
J Anal Toxicol. 2020 Jul 31:bkaa090. doi: 10.1093/jat/bkaa090.
Evaluating the hip-flask defence using analytical data from ethanol and ethyl glucuronide. A comparison of two models. Höiseth G, Nilsson GH, Lundberg R, Forsman M, Kronstrand C, Nyström I, Oscarsson C, Ericsson E, Cherma MD, Ahlner J, Kugelberg FC, Kronstrand R. Forensic Sci Int. 2020 Aug 26;316:110409. doi: 10.1016/j.forsciint.2020.110409
Association of coincident self-reported mental health problems and alcohol intake with all-cause and cardiovascular disease mortality: A Norwegian pooled population analysis. Degerud E, Høiseth G, Mørland J, Ariansen I, Graff-Iversen S, Ystrom E, Zuccolo L, Næss Ø.PLoS Med. 2020 Feb 3;17(2):e1003030
Fatal liver failure after therapeutic doses of paracetamol in a patient with Duchenne muscular dystrophy and atypical pharmacogenetic profile of drug-metabolizing enzymes. Lao YE, Molden E, Kringen MK, Annexstad EJ, Saeverud HA, Jacobsen D, Hovda KE. Basic Clin Pharmacol Toxicol. 2020 Jan 24. doi: 10.1111/bcpt.13389. Online ahead of print.
Impact of genotype-predicted CYP2D6 metabolism on clinical effects and tolerability of metoprolol in patients after myocardial infarction - a prospective observational study. Anstensrud AK, Molden E, Haug HJ, Qazi R, Muriq H, Fosshaug LE, Spigset O, Øie E. Eur J Clin Pharmacol. 2020 May;76(5):673-683.
Prescribed Doses of CYP2D6-Metabolized Drugs and Hemodynamic Responses in Relation to CYP2D6 Genotype Among Older Patients Exposed to Polypharmacy. Romskaug R, Wyller TB, Straand J, Kersten H, Molden E. Drugs Aging. 2020 Apr 29. doi: 10.1007/s40266-020-00763-0. Online ahead of print.
The Influence of Combined CYP2D6 and CYP2C19 Genotypes on Venlafaxine and O-Desmethylvenlafaxine Concentrations in a Large Patient Cohort. Kringen MK, Bråten LS, Haslemo T, Molden E.
J Clin Psychopharmacol. 2020 Mar/Apr;40(2):137-144.
Impact of age and CYP2D6 genetics on exposure of aripiprazole and dehydroaripiprazole in patients using long-acting injectable versus oral formulation: relevance of poor and intermediate metabolizer status. Tveito M, Molden E, Høiseth G, Correll CU, Smith RL.
Eur J Clin Pharmacol. 2020 Jan;76(1):41-49.
Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients. Bråten LS, Haslemo T, Jukic MM, Ingelman-Sundberg M, Molden E, Kringen MK. Neuropsychopharmacology. 2020 Feb;45(3):570-576.
A Comparative Analysis of Cytochrome P450 Activities in Paired Liver and Small Intestinal Samples from Patients with Obesity. Krogstad V, Peric A, Robertsen I, Kringen MK, Wegler C, Angeles PC, Hjelmesæth J, Karlsson C, Andersson S, Artursson P, Åsberg A, Andersson TB, Christensen H. Drug Metab Dispos. 2020 Jan;48(1):8-17.
Oral Fluid to Blood Concentration Ratios of Different Psychoactive Drugs in Samples from Suspected Drugged Drivers.
Bakke E, Høiseth G, Furuhaugen H, Berg T, Arnestad M, Gjerde H.
Ther Drug Monit. 2020 Oct;42(5):795-800.
Blood concentrations of designer benzodiazepines: Relation to impairment and findings in forensic cases. Heide G, Høiseth G, Middelkoop G, Øiestad ÅML. J Anal Toxicol. 2020 Dec 12;44(8):905-914.

2019

Nye anbefalinger ved serumkonsentrasjonsmålinger av sentralstimulerende legemidler. Frost J, Bernard JP, Dietrichs ES, Kjeldstadli K, Riedel B, Skråstad RB, Vevelstad M, Helland A. Tidsskr Nor Laegeforen. 2019 Sep 23;139(13).
A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia. Solberg DK, Refsum H, Andreassen OA, Bentsen H. Acta Neuropsychiatr. 2019 Aug;31(4):202-212.
Prevalence and risk factors of drug-related hospitalizations in multimorbid patients admitted to an internal medicine ward. Lea M, Mowe M, Mathiesen L, Kvernrød K, Skovlund E, Molden E. PLoS One. 2019 Jul 22;14(7):e0220071.
Forskrivning av antipsykotika til hjemmeboende eldre 2006–18. Tveito M, Handal M, Engedal K, Smith RL, Høiseth G, Skurtveit S. Tidsskr Nor Laegeforen. 2019 Oct 29;139(16).
The Effect of Valproic Acid on Olanzapine Serum Concentration: A Study Including 2791 Patients Treated With Olanzapine Tablets or Long-Acting Injections. Tveito M, Smith RL, Høiseth G, Molden E. J Clin Psychopharmacol. 2019 Nov/Dec;39(6):561-566
Reduction in N-Desmethylclozapine Level Is Determined by Daily Dose But Not Serum Concentration of Valproic Acid-Indications of a Presystemic Interaction Mechanism. Smith RL, Kyllesø L, Haslemo T, Andreassen OA, Molden E. Ther Drug Monit. 2019 Aug;41(4):503-508.
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental Oral Dosing. Bruun LD, Kjeldstadli K, Temte V, Birdal M, Bachs L, Langødegård M, Strand DH, Gaare KI, Øiestad E, Høiseth G. J Anal Toxicol. 2019 Jun 1;43(5):369-377.
Effect of CYP4F2, VKORC1, and CYP2C9 in Influencing Coumarin Dose: A Single-Patient Data Meta-Analysis in More Than 15,000 Individuals. Danese E, Raimondi S, Montagnana M, Kringen MK et al. Clin Pharmacol Ther. 2019 Jun;105(6):1477-1491.
Effect of CYP2D6 genotype on exposure and efficacy of risperidone and aripiprazole: a retrospective, cohort study. Jukic MM, Smith RL, Haslemo T, Molden E, Ingelman-Sundberg M. Lancet Psychiatry. 2019 May;6(5):418-426.
Substantial Differences in Serum Concentrations of Psychoactive Drugs Measured in Samples Stored for 2 Days or More on Standard Serum Tubes Versus Serum Tubes Containing Gel Separators. Wollmann BM, Lunde HA, Støten LK, Lunder N, Molden E. Ther Drug Monit. 2019 Jun;41(3):396-400.
Critical appraisal of adverse effects reporting in the 'Treatment for Adolescents WithDepression Study (TADS)'. Westergren T, Narum S, Klemp M. BMJ Open. 2019; 9(3): e026089.
Detection Time of Oxazepam and Zopiclone in Urine and Oral Fluid after Experimental OralDosing. Bruun LD, Kjeldstadli K, Temte V, Birdal M, Bachs L, Langødegård M, Strand DH, Gaare KI, Øiestad E, Høiseth G. J Anal Toxicol. 2019 Jan 7. doi: 10.1093/jat/bky083. [Epub ahead of print].
Significantly lower CYP2D6 metabolism measured as the O/N-desmethylvenlafaxine metabolic ratio in carriers of CYP2D6*41 versus CYP2D6*9 or CYP2D6*10: a study on therapeutic drug monitoring data from 1003 genotyped Scandinavian patients. Haslemo T, Eliasson E, Jukić MM, Ingelman-Sundberg M, Molden E. Br J Clin Pharmacol. 2019; 85(1): 194-201.
An Experimental Study of Diazepam and Alprazolam Kinetics in Urine and Oral Fluid Following Single Oral Doses. Temte V, Kjeldstadli K, Bruun LD, Birdal M, Bachs L, Karinen R, Middelkoop G, Øiestad E, Høiseth G. J Anal Toxicol. 2019 Mar 1;43(2):104-111.
En jente i tidligskolealder uten effekt av opioider ved generell anestesi. Olsen TCR, Rasmussen AR, Kringen MK, Molden E. Tidsskr Nor Laegeforen. 2019;139(7). doi: 10.4045/tidsskr.18.0561.
Effect of Grapefruit Juice Intake on Serum Level of the Endogenous CYP3A4 Metabolite4β-Hydroxycholesterol-an Interaction Study in Healthy Volunteers. Gjestad C, Hole K, Haslemo T, Diczfalusy U, Molden E. AAPS J. 2019; 21(4): 58.
Tvangsbehandling av somatisk sykdom ved psykisk lidelse. Bjorå IKH, Jorem J, Tveito M. Tidsskr Nor Laegeforen. 2019 Feb 8;139(3).
HairEtG: Alterations in segment levels accompanying hair growth. Fosen JT, Høiseth G, Sempio C, Giarratana N, Enger A, Mørland J, Morini L. Drug Test Anal. 2019 Jan;11(1):112-118.
Adipokine levels are associated with insulin resistance in antipsychotics usersindependently of BMI. Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG. Psychoneuroendocrinology. 2019; 103: 87-95.
Serum Concentrations and Elimination Rates of Direct-Acting Oral Anticoagulants(DOACs) in Older Hip Fracture Patients Hospitalized for Surgery: A Pilot Study. Viktil KK, Lehre I, Ranhoff AH, Molden E. Drugs Aging 2019; 36(1): 65-71.
Detection of Drugs in Simultaneously Collected Samples of Oral Fluid and Blood. Bakke E, Høiseth G, Arnestad M, Gjerde H. J Anal Toxicol. 2019; 43(3): 228-232.

2018

Farmakologiske aspekter relater til bruk av antidepressiva hos eldre. Waade RB. NFT 2018; 6: 28-30.
Age Impacts Olanzapine Exposure Differently During Use of Oral Versus Long-ActingInjectable Formulations: An Observational Study Including 8,288 Patients. Tveito M, Smith RL, Molden E, Haslemo T, Refsum H, Hartberg C, Correll CU, Høiseth G. J Clin Psychopharmacol. 2018; 38(6):570-576.
Free thyroxine and thyroid-stimulating hormone in severe mental disorders: Anaturalistic study with focus on antipsychotic medication. Vedal TSJ, Steen NE, Birkeland KI, Dieset I, Reponen EJ, Laskemoen JF, Rødevand L, Melle I, Andreassen OA, Molden E, Jönsson EG. J Psychiatr Res. 2018; 106:74-81.
Elevated 4β-hydroxycholesterol/cholesterol ratio in anorexia nervosa patients. Hole K, Heiberg PL, Gjestad C, Mehus LL, Rø Ø, Molden E. Pharmacol Res Perspect. 2018 Sep 11;6(5):e00430.
Lifecourse socioeconomic position, alcohol drinking patterns in midlife, and cardiovascularmortality: Analysis of Norwegian population-based health surveys. Degerud E, Ariansen I, Ystrom E, Graff-Iversen S, Høiseth G, Mørland J, Davey Smith G, Næss Ø. PLoS Med. 2018 Jan 2; 15(1):e1002476.
Fatal Adverse Event with Dabigatran in Elderly Patient with Reduced Kidney Function. Havig SM, Lea D, Krpo M, Skari RM, Gustavsen I, Høiseth G. Basic Clin Pharmacol Toxicol. 2018 Aug; 123(2):221-226.
Afatal blood concentration of 5-APB. Krpo M, Luytkis HC, Haneborg AM, Høiseth G. Forensic Sci Int. 2018 Oct;291:e1-e3.
Impactof CYP2C19 Genotype on Escitalopram Exposure and Therapeutic Failure: ARetrospective Study Based on 2,087 Patients. Jukić MM, Haslemo T, Molden E, Ingelman-Sundberg M. Am J Psychiatry. 2018; 175(5): 463-70.
Comparison of CYP3A4-Inducing Capacity of Enzyme-Inducing Antiepileptic Drugs Using 4β-Hydroxycholesterol as Biomarker. Hole K, Wollmann BM, Nguyen C, Haslemo T, Molden E. Ther Drug Monit. 2018; 40(4): 463-68.
Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration is Restricted toPostmenopausal Females - a Study Matching Therapeutic Drug Monitoring andGenotype Data from 534Patients. Smith RL, Haslemo T, Chan HF, Refsum H, Molden E. Ther Drug Monit. 2018; 40(5): 567-571.
Treatment With Antipsychotics in Pregnancy: Changes in Drug Disposition. Westin AA, Brekke M, Molden E, Skogvoll E, Castberg I, Spigset O. Clin Pharmacol Ther. 2018; 103(3): 477-84.
Utilisation and polypharmacy aspects of antiepileptic drugs in elderly versus youngerpatients with epilepsy: A pharmacoepidemiological study of CNS-active drugs inNorway, 2004-2015. Baftiu A, Feet SA, Larsson PG, Burns ML, Henning O, Sætre E, Molden E, Granas AG, Johannessen SI, Landmark CJ. Epilepsy Res. 2018; 139: 35-42.
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regionsunder strong background selection. Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Et al. inkl Molden E. Nat Genet. 2018; 50(3): 381-89.
Serumkonsentrasjonsmålinger av DOAK-legemidler. Dyrkorn R, Lundgaard H, Stokes CL, Molden E, Spigset O. Tidsskr Nor Laegeforen. 2018; 138(7): doi: 10.4045 /tidsskr.18.0237.
Hvem bør få klopidogrel etter hjerneslag? Ihle-Hansen H, Hagberg G, Molden E, Myrstad M. Tidsskr Nor Laegeforen. 2018; 138(9): doi: 10.4045 /tidsskr.18.0277.
Characterization of gastrointestinal adverse effects reported in clinical studies ofcorticosteroid therapy. Westergren T, Narum S, Klemp M. J Clin Epidemiol. 2018; 94: 19-26.
Cardiometabolic risk factors, physical activity and psychiatric status in patients in long-termpsychiatric inpatient departments. Ringen PA, Faerden A, Antonsen B, Falk RS, Mamen A, Rognli EB, Solberg DK, Andreassen OA, Martinsen EW. Nord J Psychiatry. 2018; 72(4): 296-302.
Using motivational techniques to reduce cardiometabolic risk factors in long termpsychiatric inpatients: a naturalistic interventional study. Ringen PA, Falk RS, Antonsen B, Faerden A, Mamen A, Rognli EB, Solberg DK, Martinsen EW, Andreassen OA. BMC Psychiatry. 2018; 18(1): 255.
The Appearance, Taste, and Concentrations of Zolpidem Dissolved in Still Water andCarbonatedBeverages. Heide G, Hjelmeland K, Brochmann GW, Karinen R, Høiseth G. J Forensic Sci. 2018; 63(3): 911-914.
Is Hair Analysis Useful in Postmortem Cases? Høiseth G, Arnestad M, Karinen R, Morini L, Rogde S, Sempio C, Vindenes V, Øiestad ÅML. J Anal Toxicol. 2018; 42(1): 49-54.
Lifecourse socioeconomic position, alcohol drinking patterns in midlife, andcardiovascular mortality: Analysis of Norwegian population-based healthsurveys. Degerud E, Ariansen I, Ystrom E, Graff-Iversen S, Høiseth G, Mørland J, Davey Smith G, Næss Ø. PLoS Med. 2018; 15(1): e1002476.
Fatal Adverse Event with Dabigatran in Elderly Patient with Reduced Kidney Function. Havig SM, Lea D, Krpo M, Skari RM, Gustavsen I, Høiseth G. Basic Clin Pharmacol Toxicol. 2018; 123(2): 221-226.
Associations between cytokine levels and CYP3A4 phenotype in patients with rheumatoid arthritis. Wollmann BM, Syversen SW, Vistnes M, Lie E, Mehus LL, Molden E. Drug Metab Dispos. 2018 oct; 46(10): 1384-9.

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